Dr. Krystal is the Chair of the Department of Psychiatry at Yale and is a leading expert in alcoholism, post-traumatic stress disorder, schizophrenia, and depression. His work links psychopharmacology, neuroimaging, molecular genetics, and computational neuroscience to study the neurobiology and treatment of these disorders. He is best known for leading the discovery of the rapid antidepressant effects of ketamine in depressed patients. He is a member of the U.S. National Academy of Medicine. He also serves in a variety of advisory and review capacities for NIAAA, NIMH, Wellcome Trust, Brain, and Behavior Research Foundation, the Broad Institute, the Karolinska Institute, and the U.S. Department of Veterans Affairs.